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Excellent, Without a doubt!!

Don't listen to the negative reviews

This movie was so-so. It had it's moments, but wasn't the greatest.

Unshakable, witty and deeply felt, the film will be paying emotional dividends for a long, long time.

When I first watched this film, I thought it was amazing. I have recently seen the film again and it was rather disappointing. The idea is still really good and if they'd re-film it, use more experienced people, I think it could be really good. Although the voice actors are people I really like, the performance was very poor. It all seemed to be too amateurish. Young kids, especially the boys, will still like it because it is rather disgusting. No really, it is absolutely disgusting. Under no circumstance watch this film if you are eating. It will take your appetite away.... at very least. The best thing in the film was Bill Murray, but it's a film he could have done without.

This is a very cool live-action/animated movie starring Bill Murray as Frank Detorre, who after eating some bad food contracted a life-threatening virus. In the movie, the internal organs of Frank's body is an animated world known as the City of Frank, and is where a policeman white blood cell named Osmosis Jones (Chris Rock) and a cold pill Frank took named Drix (David Hyde Pierce) attempt to stop the virus known as Drax (Lawrence Fishburne) from claiming Frank's life.I thought this movie is very clever and imaginative, putting the human body into a whole new perspective. It makes your "insides" seem like an entire and adventurous different world, where in the film the white blood cells are law enforcement officers, lymph nodes are police stations, veins are highways, blood is water/lava, stomach is a bus station, a rowdy club is a pimple, and the germs and bacteria are the criminals.Marc Hyman wrote a fun, imaginative and adventurous script for the movie, cleverly depicting (in animation) how the human body fights infections and sickness. Brothers Bobby and Peter Farrelly did a fine job directing the film, making you suspend reality and imagining your body working like it is depicted in the film. Kudos to the team who did the animation work - bright, colorful and vibrant - nothing like some of those dull-looking and washed-out CGI animation you see nowadays. And, the live-acting and voice casting were great - realistic and believable.As this movie is raged PG, there is also quite a bit of bodily humor, puns and jokes, especially involving digestion, going to the restroom, passing gas, popping pimples from the face, food in the mouth.. (you get the drill). Therefore, you may not want to eat anything while watching this movie. But overall, it's a fun movie for both kids and adults - very entertaining! Grade B+

The Farrelly brothers are dipping into the animation pool. It's colorful and primitive animation. It's pretty good, but that's not really the problem. Surprisingly the problem is Bill Murray and live action stuff.Frank Detomello is a slob. He eats a hard boiled egg covered with a deadly germ. And we travel inside Frank to see white blood cell policeman Osmosis Jones (Chris Rock) battle evil virus Thrax (Laurence Fishburne) with the help of Drix (David Hyde Pierce).Bill Murray looks awful as he gets sicker and sicker. I have to ask if we're supposed to laugh at Bill? It's just gross. Not the gross out humor that the Farrellys are known for. It isn't funny at all.The animated sections are much better. In fact I prefer they cut out the live action stuff. Chris Rock does a good voice. He has good chemistry with David Hyde Pierce's Drix. They need a few more jokes, but I like the City of Frank.

I am a substitute teacher. Middle-school science teachers often leave this movie in lieu of a lesson plan. This is unfortunate because the movie teaches nothing and is also not entertaining.As best I can tell, the producers saw one of those "Science is COOL!" posters -- feeble propaganda that fools nobody and embarrasses those who do like science -- and said, "let's make a movie of it!" They decked it out with a star-filled cast and plenty of fart/poop/bodily fluid jokes. It never adds up to any more than the poster. But you can look away from a poster. This just keeps going, and going, and going. (And normally I have to show it to FIVE CLASSES).The problem is that no age group will get anything from this movie. It is not engaging or funny enough for teens and adults, and has enough gross jokes to alienate many of the latter. Elementary-school kids might like the animation and goofy/stereotypical story.There is no scientific lesson here. The only lesson is, "Eat healthy and exercise." I'm pretty sure we don't need a 90-minute movie to get that across.Teachers, please knock it off already!