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This is one of the few movies I've ever seen where the whole audience broke into spontaneous, loud applause a third of the way in.

This is a coming of age storyline that you've seen in one form or another for decades. It takes a truly unique voice to make yet another one worth watching.

The film may be flawed, but its message is not.

It is a whirlwind of delight --- attractive actors, stunning couture, spectacular sets and outrageous parties. It's a feast for the eyes. But what really makes this dramedy work is the acting.

Rare independent film about the nature of love, is love and feelings all chemistry or are humans blessed with something special that no other animal has? Well produced and with an excellent cast this film is carries along softly and yet never boring. Everything feels real and interesting. The director is a born filmmaker, unfortunately I don't see any other films-to his credit. We should see more of this very talented cast in the future. Checkout Nicole Wilder as Machiko, you can't play cute and sensual any better than that. Hope to see more films from this director and cast. If you are tired of watching the same crap over and over again, get yourself some Dopamine.

It's a wonderful movie. The premise is clever. All of the acting is well done. The character, Sarah (Sabrina Lloyd) really caries this movie, as Rand (John Livingston) is a likable underdog type that you instantly root for, but Sarah, while likable, has a darker side and if the audience doesn't care about her then the movie falls apart. A less charismatic and talented actress could not have pulled this part off, but Sabrina Lloyd seems to handle it with a natural charm that makes it look easy. I have no doubt that she will have many opportunities thrown her way based upon her work here.This is a great movie, however a few minor details could have made it better. At just over 80 minutes, they really could have filled out the movie a little more. I can't help but feel that there is a lot of story left untold and some of the scenes feel a little disjointed. With it being an independent feature, I'm sure a lot of this has to do with budget and time (trying to get into Sundance.) I also would have enjoyed a few more light moments between characters.I think one of the reasons some people haven't taken to it is the mistaken idea that it is a romantic comedy. It really isn't. There are a few light moments (don't know if I would even call them comedic moments), but this is definitely a drama. The issues and material are serious, so anyone waiting for Sandra Bullock type goofiness, Meg Ryan over sentiment or Three's Company sexual innuendo miscommunication are going to be disappointed.

Greetings again from the darkness. Saw the Dallas premiere this evening and co-writer Tim Breitbach and lead actor John Livingston were in attendance and held a Q&A after the showing. Really liked the premise of the movie ... the whole science vs. nature/feelings thing. Thought John Livingston was excellent in his role as Rand, the computer genius who struggles with his feelings in real life. Livingston reminds of a less egotistical, more talented Ben Affleck. He is a true actor. Sabrina Lloyd (veteran of many TV shows) displays the darkness and vulnerability and toughness necessary for her role. Her very expressive eyes go along way towards silent conversation. You can almost taste her pain. Just a little disappointed with some of the stereotypes and weak dialog in parts. Other parts were brilliant and I can understand why it was selected for Sundance Film Festival. Would have enjoyed just a bit more of the three man creative process that was displayed in hyper speed to keep the audience from being bored. After 3 years on the same project, I was very interested in the group dynamics. Overall worth seeing, with some excellent parts, as well as some inconsistencies in quality of scenes.

Chemistry or chemical ? Haven't you ever wondered why we connect with certain people or sometimes why we don't ? Dacena (apparently a first time director) and his team have done an amazing job telling a story about the question that moves us all ... where does love come from ? Dopamine tells us of the very real and emotional journey of its characters through smart dialog, humor and a unique story against a backdrop of the post-dot.com Bay Area (filmed with great shots that are not the typically canned footage of San Fran). A great film that knows the audience isn't stupid. I can't wait for the next work by this team.